The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy supplies – such as after exercise or in between meals – signaled by increases in AMP or ADP and decreases in ATP.
Once activated, AMPK acts to restore energy homeostasis by promoting ATP-producing catabolic pathways and inhibiting energy-consuming processes.
AMPK is highly diverse. In humans, there are multiple alpha, beta, and gamma subunits that combine into 12 possible trimeric combinations of AMPK. Some tissues – like the liver and skeletal muscle – express complexes with specific subunit isoforms.
It has been historically difficult for drug developers to safely target all 12 versions of human AMPK.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
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This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
AMPK is involved in over 100 different cellular pathways. For example, after exercise, the active form of AMPK increases glucose and fatty acid metabolism to replete cellular ATP while also initiating key cellular recycling mechanisms.
AMPK controls many pathways that are involved in aging processes. With aging, AMPK signaling is diminished, reducing function in different tissues. Even in low energy states – like after exercise – activity of some specific AMPK complexes may remain low.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
Despite considerable efforts, no direct AMPK activator has yet made it through development. Recent advancements in our understanding of AMPK activation have renewed interest in AMPK as a molecular target. Safely activating AMPK in humans has the potential to treat multiple cardiometabolic and aging-related diseases.
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This paragraph is ~100 characters, 30 words, should describe more about Cambrian Biopharma
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