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AMPK and mitochondria work together to maintain cellular energy balance. AMPK senses when energy levels are low and brings additional sugar and fat into the cell. Mitochondria use the fats and sugars as fuel to create ATP, the energy source for everything from movement to digestion to thinking.
When either system falters, cells lose the ability to effectively adapt to energy demand.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
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This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
With aging and chronic nutrient excess, AMPK signaling becomes less responsive, and mitochondria become less active.
This dual loss reduces metabolic flexibility—cells become less able to switch from a basal metabolic state into a highly active metabolism. This lack of metabolic flexibility can reduce endurance and exercise tolerance and, over time, contributes to frailty that accompanies old age.
Physical activity provides a natural reset for cellular energy metabolism. Exercise activates AMPK and promotes mitochondrial biogenesis, increasing glucose uptake and fatty acid oxidation to restore ATP levels.
Amplifier’s research explores ways to pharmacologically reproduce these exercise-driven effects in metabolically impaired tissues, helping restore flexibility and resilience.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
ATX-304 restores metabolic function by activating AMPK and increasing mitochondrial activity. In preclinical studies, ATX-304 reduced fat mass and improved glucose and lipid metabolism without decreasing food intake.
Mechanistically, ATX-304 enhances mitochondrial respiration, increases fatty-acid oxidation, and reduces liver steatosis, rebalancing energy systems disrupted by age or disease.
Amplifier’s approach builds on decades of research, translating discoveries about metabolic aging into new medicines that can safely restore healthy metabolism.
By improving the cellular processes that regulate energy balance, we aim to advance how metabolic health can be maintained and sustained across metabolic diseases and during natural aging.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
